Dissolution behaviors and gastrointestinal absorption of tolbutamide in tolbutamide-polyvinylpyrrolidone coprecipitate.
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چکیده
منابع مشابه
The Effects of Tolbutamide
The effects of chronic tolbutamide treatment were examined in a diabetic animal model in which abnormal myocardial function and composition have previously been demonstrated. Eight diabetic dogs were given tolbutamide 250 mg/day orally and compared with seven untreated diabetics, five healthy dogs receiving tolbutamide, and eight normal controls. After one year, resting hemodynamic studies in t...
متن کاملEffects of aging on crystallization, dissolution and absorption characteristics of amorphous tolbutamide-2-hydroxypropyl-beta-cyclodextrin complex.
The effects of storage on the crystallization, dissolution and absorption of tolbutamide from amorphous tolbutamide-2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) complex were investigated, in comparison with those of polyvinylpyrrolidone (PVP) solid dispersion. The amorphous solid complex of tolbutamide with HP-beta-CyD and the solid dispersion of tolbutamide with PVP were prepared by a spray...
متن کاملHost-guest chemistry of tolbutamide.
The molecular recognition features of tolbutamide with four synthetic hosts have been studied by means of NMR titrations, NOESY experiments and Monte Carlo (MC) conformational search. The interaction strength and the most probable structure reveal new insights on the recognition phenomena of this urea derivative in comparison with close related compounds.
متن کاملPotentiation of Paraldehyde Hypnosis by Tolbutamide.
Beaser (1958) has recorded that prior administration of tolbutamide produces an intolerance to alcohol in the form of hot flushes. Disulfiram produces such an intolerance in a more marked· way. Keplinger and· Wells (1957) have reported that disulfiram prolongs the hypnotic effect of paraldehyde in mice. Hence it is possible that tolbutamide may have some action on paraldehyde anaesthesia analog...
متن کاملEffect of Solvent on Crystal Habit and Dissolution Behavior of Tolbutamide by Initial Solvent Screening
By an initial solvent screening of 18 solvents, 14 pure good solvents were selected for the crystallization of tolbutamide. Solid generation by the solvent-change method was carried out using the pure good solvents. Crystals were generated in only 10 of the 14 solvents. Different crystal forms of tolbutamide were obtained. Crystals were subjected to evaluation tests such as differential scannin...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1979
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.27.31